Within seconds after birth, a flap of tissue known as the septum primum that previously acted as a valve closes the foramen ovale and establishes the typical cardiac circulation pattern.
12.
Shortly after birth it fuses with the septum primum, and consequently the foramen ovale is closed, but sometimes the fusion is incomplete and the upper part of the foramen remains patent.
13.
The part of the septum primum that remains to the left of the septum secundum acts as a one way flow valve due to the greater pressures in the right atrium compared to the left atrium.
14.
A second entity, the septum secundum, develops to the right of the septum primum and the opening between the upper and lower limbs of the septum secundum is known as the foramen ovale of the heart.
15.
During heart development of a human embryo, the cavity of the primitive atrium becomes subdivided into right and left chambers by a septum, the "'septum primum "', which grows downward into the cavity.
16.
In normal physiologic circumstances the septum primum acts as a one way valve preventing blood flow as described above, however if pathologic conditions cause right atrial pressure to exceed left atrial pressure, blood may flow through the foramen ovale from right to left.
17.
On day 28, areas of tissue in the heart tube begin to expand inwards; after about two weeks, these expansions, the membranous " septum primum " and the muscular " endocardial cushions ", fuse to form the four chambers of the heart.
18.
Cells in part of the septum primum die creating a hole while muscle cells, the " septum secundum ", grow along the right atrial side the septum primum, except for one region, leaving a gap through which blood can pass from the right artium to the left atrium, the foramen ovale.
19.
Cells in part of the septum primum die creating a hole while muscle cells, the " septum secundum ", grow along the right atrial side the septum primum, except for one region, leaving a gap through which blood can pass from the right artium to the left atrium, the foramen ovale.
20.
This opening is closed by the union of the septum primum with the septum intermedium, and the communication between the atria is re-established through an opening which is developed in the upper part of the septum primum; this opening is known as the foramen ovale ( ostium secundum of Born ) and persists until birth.
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