Because antivenin is derived from animal antibodies, people generally display an allergic response during infusion, known as serum sickness.
12.
In the same year, Clemens Pirquet and Bela Schick described serum sickness in children receiving large quantities of horse-derived antitoxin.
13.
Serum sickness is a type III hypersensitivity reaction that occurs one to three weeks after exposure to drugs including penicillin.
14.
Side effects of infliximab, like other immunosuppressants of the allergic reactions, risk of re-activation of tuberculosis, serum sickness, and risk of multiple sclerosis.
15.
Rituximab's major side effect is serum sickness, commonly described as an " allergic reaction ", which can be severe, especially on the first infusion.
16.
In vivo hepatic drug biotransformation studies have shown greater lymphocyte killing in subjects with a known history of serum sickness-like reactions than in control subjects.
17.
Patients who are immunized with the antibodies from animals may develop serum sickness due to the proteins from the immune animal and develop serious allergic reactions.
18.
To prevent serum sickness, it is often best to use antitoxin generated from the same species ( e . g . use human antitoxin to treat humans ).
19.
Patients stay in the hospital as long as three weeks to give the immune system time to recover to a point where there is no longer a risk of serum sickness.
20.
Many of the antibodies it contains are useless because they target harmless components of the venom, and it can also cause nasty side effects such as anaphylactic shock or serum sickness.
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