Cardiovascular effects have been recorded with bradycardia and sinus arrhythmia being consistently recorded in 68 % of patients treated with mefloquine ( in one hospital-based study ).
12.
Activity in this range is associated with the respiratory sinus arrhythmia ( RSA ), a vagally mediated modulation of heart rate such that it increases during inspiration and decreases during expiration.
13.
It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility.
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This theory decomposes heart rate variability based on frequency domain characteristics with an emphasis on respiratory sinus arrhythmia and its transmission by a neural pathway that is distinct from other components of HRV . There is anatomic and physiological evidence for a polyvagal control of the heart.
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