This can be mistaken for sinus bradycardia if the APC is buried in the t wave since the APC will reset the SA node and lead to a long P-P interval.
12.
Sinus bradycardia can also be an adaptive advantage; for example, diving seals may have a heart rate as low as 12 beats per minute, helping them to conserve oxygen during long dives.
13.
The third, sick sinus syndrome, covers conditions that include severe sinus bradycardia, sinoatrial block, sinus arrest, and bradycardia-tachycardia syndrome ( atrial fibrillation, flutter, and paroxysmal supraventricular tachycardia ).
14.
The Bezold Jarisch reflex is responsible for the sinus bradycardia that commonly occurs within the first 60 minutes following an acute myocardial infarction, and explains the occurrence of AV node block in the context of acute posterior or inferior myocardial infarction.
15.
This is complemented by gastro-coronary reflexes whereby the coronary arteries constrict with " functional cardiovascular symptoms " similar to chest-pain on the left side and radiation to the left shoulder, dyspnea, sweating, up to angina pectoris-like attacks with extrasystoles, drop of blood pressure, and tachycardia ( high heart beat ) or sinus bradycardia ( heart beat below 60 ).
16.
For example, an inherited mutation of a highly conserved residue in the CNBD of the HCN4 protein ( S672R ) is associated with inherited sinus bradycardia . " In vitro " studies indicate that the S672R mutation causes a hyperpolarizing shift of the HCN4 channel open probability curve of about 5 mV in heterozygosis, an effect similar to the hyperpolarizing shift caused by parasympathetic stimulation and able to explain a reduction of inward current during diastole and the resulting slower spontaneous rate.
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