11. Spectrin is a cytoskeletal protein that lines the intracellular side of the plasma membrane in eukaryotic cells.12. "' Spectrin repeats "'are found in several proteins involved in cytoskeletal structure. 13. MACF1 encodes a large protein containing numerous spectrin and leucine-rich repeat ( LRR ) domains. 14. PRC1 s rod domain adopts multiple conformations, all affected by its C-terminal spectrin domain. 15. In animal models of disease and injury, alpha II-spectrin has been implicated in diverse functions. 16. Spectrin proteins and actin microfilaments are attached to transmembrane proteins by attachment proteins between them and the transmembrane proteins.17. Mutations of spectrin and protein 4.1 are associated with elliptocytosis or spherocytosis and anemia of varying severity. 18. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin . 19. Elevated protein expression of alpha II-spectrin has been detected in cerebrospinal fluid in patients with Guillain Barr?syndrome. 20. The major attachment sites between the erythrocyte spectrin -actin cytoskeleton and the lipid bilayer are glycophorin C and band 3.
