11. Sphingolipid metabolites, such as ceramide, sphingosine and sphingosine-1-phosphate, are SphK2. 12. Sphingolipid metabolites, such as ceramide, sphingosine and sphingosine -1-phosphate, are SphK2. 13. Sphingolipids at large form a class of lipids characterized by a particular aliphatic aminoalcohol, which is sphingosine . 14. The structure of sphingomyelin was first reported in 1927 as N-acyl-sphingosine -1-phosphorylcholine. 15. This reaction is a key step in the biosynthesis of sphingosine which is a precursor of many other sphingolipids. 16. The only route by which sphingolipids are converted to non-sphingolipids is through sphingosine -1-phosphate lyase. 17. The systematic name of this enzyme class is "'CDP-choline : sphingosine cholinephosphotransferase " '. 18. This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. 19. This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. 20. This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate.