P62 is a serine / threonine rich protein of ~ 520 amino acids, with tetrapeptide repeats on the amino terminus and a series of alpha-helical regions with hydrophobic heptad repeats forming beta-propeller domain.
12.
This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER . In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein.
13.
Retention of resident soluble proteins in the receptor that recognizes and binds the tetrapeptide-containing protein and then returns it to the ER . In yeast, the sorting receptor is encoded by a single gene, ERD2, which is a seven-transmembrane protein.
14.
SUMO-modified proteins contain the tetrapeptide motif B-K-x-D / E where B is a hydrophobic residue, K is the lysine conjugated to SUMO, x is any amino acid ( aa ), D or E is an acidic residue.
15.
"' Bendavia "'( or SS-31 ) is a small mitochondrially-targeted tetrapeptide ( D-Arg-dimethylTyr-Lys-Phe-NH2 ) that scavenges mitochondrial reactive oxygen species, inhibits the mitochondrial permeability transition ( MPT ) pore, and stabilizes cardiolipin.
16.
Following experimental elucidation of SMAC structure, small-molecule SMAC mimetics have been developed to mimic the tetrapeptide AVPI in the IAP binding domain of SMAC, which is responsible for binding the BIR3 domains in IAPs like XIAP, cIAP1, and cIAP2 to induce cell death, and sometimes, necroptosis.
17.
Some of the multiple activities of thymosin ? 4 unrelated to actin may be mediated by a tetrapeptide enzymically-cleaved from its N-terminus, N-acetyl-ser-asp-lys-pro, brand names Seraspenide or Goralatide, best known as an inhibitor of the proliferation of haematopoietic ( blood-cell precursor ) stem cells of bone marrow.
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