11. The therapeutic index also factors whether a drug can be used as a time release drug. 12. With an acceptable therapeutic index in humans, nitrogen mustards were first introduced in the clinic in 1946. 13. A low therapeutic index indicates that there is a high risk of toxicity when using the drug. 14. For instance most formularies will not cover barbiturates since their therapeutic index is low compared to benzodiazepines. 15. Methocarbamol has a high therapeutic index , i . e ., a wide range of safe and effective dosages. 16. Medication is said to have a narrow or wide " therapeutic index " or " therapeutic window ". 17. Nevertheless, the therapeutic index can be viewed as an upper bound to the protective index for a given substance. 18. They have a high therapeutic index , that is, phage therapy would be expected to give rise to few strain. 19. For some hepatically metabolized drugs with very low therapeutic indexes , co-administration with methimazole may not be possible at all. 20. Therapeutic index also does not take into account the ease or difficulty of reaching a toxic or lethal dose.
