11. Thiocyanate is a potent competitive inhibitor of the thyroid sodium-iodide symporter.12. Inhibition of this step requires competitive inhibitors, such as perchlorate and thiocyanate . 13. Thiocyanate salts are typically prepared by the reaction of cyanide with elemental sulfur:14. For example, tetramethylammonium thiocyanate may be made from ammonium thiocyanate, thus: 15. For example, tetramethylammonium thiocyanate may be made from ammonium thiocyanate , thus: 16. The thiocyanate is treated with sulfuric acid and then hydrolyzed with ice water. 17. Thiocyanate compounds can also corrode reinforcing but are safe at recommended dosage levels.18. Thiocyanate is a relatively non-toxic molecule and is excreted by the kidneys.19. Rhodanese catalyzes the reaction of sodium nitroprusside with thiosulfate to form the metabolite thiocyanate . 20. Common bridging ligands include the halides and the pseudohalides such as hydroxide and thiocyanate .