11. Thymidine kinase can then phosphorylate this compound into thymidine monophosphate ( TMP ). 12. Therefore . a gene for thymidine kinase must be incorporated in the genome. 13. Direct determination of the thymidine kinase protein by immunoassay has also been used. 14. Thymidine kinase has been determined in tissue samples after extraction of the tissue.15. Antibodies against thymidine kinase are available for immunohistochemical detection. 16. Cells can integrate BrdU in newly synthesized DNA as a substitute for thymidine . 17. Also the development of thymidine kinase like enzymes in the development has been studied. 18. This is due to a thymidine to cytosine mutation at the second codon position. 19. Tipiracil causes area under the curve 37-fold, by inhibiting thymidine phosphorylase. 20. In one study, researchers incorporated tritiated thymidine into dividing murine epidermal basal cells.
