Perturbations in adenylyl cyclase activity have been implicated in alcohol and opioid addiction and is associated with human diseases, including thyroid adenoma, Anthrax, precocious puberty in males and chondrodysplasia punctata diseases.
12.
It activates thyroid hormone by converting the prohormone thyroxine ( T 4 ) by outer ring deiodination ( ORD ) to bioactive thyroid, and may contribute significantly to the relative increase in thyroidal T 3 production in patients with Graves'disease and thyroid adenomas.
13.
This is supported by findings that BLT2 is abnormally expressed in many human cancers that concurrently overexpress these arachidonic acid metabolizing pathways viz ., follicular thyroid adenoma, Renal cell carcinoma, urinary bladder Transitional cell carcinoma, esophagus squamous cell carcinoma, colon adenocarcinoma, the Serous cystadenocarcinoma type of ovarian cancer, and uterine cervical carcinoma.
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