11. RNAi is under development as an insecticide, employing multiple approaches, including genetic engineering and topical application . 12. Topical applications are described as " free-radical scavengers, " combating destructive elements of sun and pollutants.13. Nevertheless, allergy to topical application has been confirmed. 14. Still, lapachol has strong antibiotic and disinfectant properties, and may be better suited for topical applications . 15. The topical applications are good for superficial pain. 16. "' Neatsfoot oil "'is a yellow oil medicinally as a topical application for dry scaly skin conditions. 17. Topical application of progesterone with the intention of systemic therapy should not be equated with local treatment.18. The topical application of enzymes and vitamin creams is a hot topic in cosmetics and skin-care circles. 19. A liquid, suppository, injection, nasal spray, inhaler, patch, or topical application will simply not be as popular. 20. Lung tumors arise after topical application in mice with coal tar, but also when it is ingested.
