11. Quantitatively, it is the ratio of the dose required to produce the desired therapeutic effect and the toxic dose . 12. The toxic dose of LA in cats is much lower than that in humans or dogs and produces hepatocellular toxicity. 13. :It's very safe unless you happen to be allergic to it; if you are, a toxic dose is about a milligram. 14. When a toxic dose of paracetamol is ingested, the normal glucuronide pathway is saturated and large amounts of NAPQI are produced. 15. Tricyclics have a narrow therapeutic index, " i . e . ", the therapeutic dose is close to the toxic dose . 16. As the child's chest was thrust out a long needle was used to inject a toxic dose of phenol into the chest. 17. The chronic toxic dose of selenite for humans is about 2400 to 3000 micrograms of selenium per day for a long time. 18. As such, one would have to consume around 250 kilograms of TVP per kilogram of body weight to reach a toxic dose . 19. In the case of selenium, for example, the toxic dose for adults is only five times the amount recommended for daily intake. 20. Only the dose makes a thing not a poison " .'It would make more sense to speak of toxicity or toxic dose .