11. These can be done to diagnose and monitor germ cell tumors and gestational trophoblastic diseases. 12. All five tumours arise from trophoblastic cells. 13. Another hypothesis states that imprinting may help protect the female from ovarian trophoblastic disease and parthenogenesis. 14. Larger bilateral cysts can develop as a result of increased HCG, in particular gestational trophoblastic disease. 15. In a normal pregnancy, trophoblastic cells aid the implantation of the fertilised egg into the uterine wall. 16. The ISET approach has also been applied to the sensitive isolation and genetic characterization of circulating fetal trophoblastic cells. 17. It is a tertiary referral centre for neurosurgery, and is a national centre of excellence for gestational trophoblastic disease. 18. Trophoblastic cells secrete hCG, and by measuring levels of hCG in the blood, doctors can monitor the course of disease.19. The cells that form gestational trophoblastic tumours are called trophoblasts and come from tissue that grows to form the placenta during pregnancy. 20. The best known of these is the Gestational Trophoblastic Disease ( see Choriocarcinoma and Hydatidiform mole ), detected by trophoblastic screening.