11. Vaccinia virus is most closely related to CPV-GRI-90.12. It contains live vaccinia virus , cloned from the same strain used in an earlier vaccine, Dryvax. 13. The vaccinia virus is commonly used as a prototype and can be consulted for further information. 14. Many suffered serious adverse reactions to the vaccinia virus that is used to help confer immunity. 15. The vaccine consists of live vaccinia virus . 16. The sera partially cross-reacted with a vaccinia virus HA preparation, suggesting a close relation between the viruses. 17. The origin of vaccinia virus and how it came to be in the vaccine are not known. 18. MVA is an attenuated vaccinia virus and does not replicate in the human body as efficiently as vaccinia. 19. Anyone who touches the vaccinated area on someone's arm or a contaminated bandage can spread the vaccinia virus . 20. To make VRG, a protein coating containing rabies antigens is added to the vaccinia virus using recombinant methods.