As a result of allelic exclusion, all the antigen receptors on an individual lymphocyte will have the same amino acid sequence in the variable domain of the heavy chain protein.
12.
Although most research into single-domain antibodies is currently based on heavy chain variable domains, Nanobodies derived from light chains have also been shown to bind specifically to target epitopes.
13.
The latter type is a heavy-chain antibody, an antibody lacking light chains, and can be used to produce single-domain antibodies, which are essentially the variable domain of an IgNAR.
14.
If the fuzzy membership functions cover 100 % of the input variable domain, then it can be proven that the behavior of the fuzzy system is fully deterministic over the entire input domain and nowhere ambiguous.
15.
Other types of bispecific antibodies have been designed to overcome certain problems, such as short bivalent and trivalent single-chain variable fragments ( scFvs ), fusion proteins mimicking the variable domains of two antibodies.
16.
The free ends of the DNA are rejoined by a process called non-homologous end joining ( NHEJ ) to link the variable domain exon to the desired downstream constant domain exon of the antibody heavy chain.
17.
In these rapidly dividing cells, the genes encoding the variable domains of the heavy and light chains undergo a high rate of point mutation, by a process called " somatic hypermutation " ( SHM ).
18.
As above, given two assignments s, t with same variable domain, we write s \ sim _ V t if s ( w ) = t ( w ) for every variable w \ in dom ( s ) \ setminus V.
19.
As the specificity of the antigen receptor is modulated by the variable domain of the light chain encoded by one of the immunoglobulin light chain loci, the specificities of B cells containing the same heavy chain recombination event can differ according to their light chain recombination event.
20.
There are five types of heavy chains : alpha, delta, epsilon, gamma and mu, all consisting of a variable domain ( VH ) and three ( in alpha, delta and gamma ) or four ( in epsilon and mu ) constant domains ( CH1 to CH4 ).
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