11. Because of their volume of distribution , lithotrophs may actually outnumber organotrophs and phototrophs in our biosphere. 12. The apparent volume of distribution for a 20 mg oral dose is 395 ( ?140 ) liters. 13. In addition, repinotan s volume of distribution at steady-state and plasma clearance are independent of dose. 14. In elderly men the elimination half-life is longer and in elderly women the volume of distribution is increased. 15. The apparent Volume of Distribution for Venetoclax is approximately 256-321 L . It is highly bound to human plasma protein. 16. The volume of distribution is 1.1-2.1 l / kg, but congestive heart failure can decrease it. 17. Hemodialysis has been suggested as a form of treatment, but is usually unfavorable due to the large volume of distribution of xylazine. 18. Calculation of the initial volume of distribution is the same calculation as that for the apparent volume of distribution, given by the equation: 19. Calculation of the initial volume of distribution is the same calculation as that for the apparent volume of distribution , given by the equation: 20. Estimate of the mean apparent volume of distribution of lamotrigine following oral administration ranges from 0.9 to 1.3 L / kg.