These individuals may present with a unique set of physical characteristics such as xanthelasmas ( yellow deposits of fat underneath the skin often presenting in the nasal portion of the eye ), tendon and tuberous xanthomas, arcus juvenilis ( the graying of the eye often characterized in older individuals ), arterial bruits, claudication, and of course atherosclerosis.
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In January 2010, Dr Vito Franco, professor of Palermo University, published research in an article in " La Stampa " newspaper and at a medical conference in Florence which suggested that the subject showed clear signs of xanthelasma, small accumulations of cholesterol-rich material under the skin, perhaps caused by problems in her biliary tract, due to hyperlipidemia, an inherited metabolic disorder.
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