21. Histone acetylation is also an important process in transcription. 22. The acetylation of p53 is indispensable for its activation. 23. Possible modifications include acetylation , methylation, phosphorylation, ubiquitination, and sumoylation. 24. Their affinity is higher for regions where multiple acetylation sites exist in proximity. 25. Another implication of histone acetylation is to provide a platform for protein binding. 26. Histone acetylation plays a key role in the regulation of eukaryotic gene expression. 27. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. 28. Acetylation of BMAL1 recruits CRY1 to suppress the transactivation of CLOCK / BMAL1.29. KLF15 activation inhibits p300-mediated acetylation of p53. 30. These include N-terminal Acetylation , N-Glycosylation, and Phosphorylation.
