While there are many thousands of single-gene-locus traits, so-called complex traits are due to the additive effects of many ( often hundreds ) of small gene effects.
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Further research suggests that when separate genes for white markings are present together, they have an additive effect, producing more white together than either gene would do alone.
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The TEF approach was developed to help assess the toxicity of DLCs and other environmental contaminants with additive effects and is currently endorsed by the World Health Organization
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LC50, EC50, PNEC, AEL . Furthermore, assumptions of additive effects from any given mixture are generally considered as a more precautionary approach compared to other available predictive concepts.
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However, reducing the level of more than one XSE in different combinational permutations seems to have an additive effect on ensuring proper sex determination and resultant dosage compensation mechanics.
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Drugs that prolong the QT interval ( e . g ., pimozide ) may have an additive effect on QT prolongation and lead to increased risk of ventricular arrhythmias.
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In the crustose coralline algae " Phymatolithon calcareum ", temperature and salinity showed an additive effect, as both of these factors increased the overall calcification rate of this encrusting alga.
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Therefore, patients receiving an opioid analgesic, general anesthetics, phenothiazines, or other tranquilizers, sedatives, hypnotics, or other CNS depressants ( including alcohol ) concomitantly with Nalbuphine may exhibit an additive effect.
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Additionally, exercise and good sleep hygiene ( e . g ., improving sleep patterns ) are thought to have an additive effect on treating dysthymic symptoms and preventing them from worsening.
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In the case of benzodiazepines, not only do they have additive effects, barbiturates also increase the binding affinity of the benzodiazepine binding site, leading to exaggerated benzodiazepine effects . ( ex.
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