21. This layer of the adrenal cortex is thought to be the primary source of serum DHEA-sulfate. 22. Additionally, hyperplasia of the adrenal cortex is infrequent. 23. The adrenal cortex produce the hormones that are essential for life such as Cortisol and Aldosterone. 24. H & E staining of the adrenal cortex . 25. Aldosterone synthase is found within the zona glomerulosa at the outer edge of the adrenal cortex . 26. These precursors are not further converted in the adrenal cortex if the cells lack 17Beta Hydroxysteroid dehydrogenase. 27. In the following decades several physicians experimented with extracts from the adrenal cortex to treat Addison's disease. 28. Mineralocorticoid hormones are synthesized in the outermost layer of the adrenal cortex known as the zona glomerulosa. 29. Mitotane alters steroid peripheral metabolism, directly suppresses the adrenal cortex and alters cortisone metabolism leading to hypocortisolism. 30. Smaller amounts of estradiol are also produced by the adrenal cortex , and, in men, by the testes.
