That in turn would lead to more cases of agranulocytosis and inevitably more deaths, the company said.
22.
Because of the risk of agranulocytosis, Clozaril is usually used to treat patients who are resistant to other drugs.
23.
One to 2 percent of people taking clozapine develop agranulocytosis and about 1 in 10, 000 die from the disorder.
24.
Granulocytopenia, agranulocytosis, and red-cell hypoplasia and aplasia, and megaloblastic anemia are rarely associated with the use of primidone.
25.
However, during these trials, an unacceptable number of patients dosed with metiamide developed agranulocytosis ( decreased white blood cell count ).
26.
Rare but serious ADRs associated with metoclopramide therapy include agranulocytosis, supraventricular tachycardia, hyperaldosteronism, neuroleptic malignant syndrome, akathisia and tardive dyskinesia.
27.
Unlike agranulocytosis which most commonly occurs in the first three months of therapy, this side effect may occur at any time during treatment.
28.
Patients in this category may be prescribed clozapine, a medication of superior effectiveness but several potentially lethal side effects including agranulocytosis and myocarditis.
29.
The risk of recurrence is approximately 40 50 % and lifelong treatment with antithyroid drugs carries some side effects such as agranulocytosis and liver disease.
30.
Symptoms and signs of agranulocytosis include infectious lesions of the throat, the gastrointestinal tract, and skin with an overall feeling of illness and fever.
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