In diabetics, the lack of insulin leads to production of an enzyme called aldose reductase, which creates a sugar that does the damage.
22.
Pfizer's drug, Alond, and Warner-Lambert's Zenarestat, are pills and attack neuropathy by inhibiting aldose reductase production.
23.
An aldose differs from a ketose in that it has a carbonyl group at the end of the carbon chain instead of in the middle.
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Polyol pathway scheme depicting both the NADPH-dependent reduction step catalyzed by aldose reductase and the NAD +-induced oxidation catalyzed by sorbitol dehydrogenase
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It has a terminal aldehyde group rather than a ketone in its linear chain, and so is considered part of the aldose family of monosaccharides.
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The systematic name of this enzyme class is "'NDP : alpha-D-aldose-1-phosphate nucleotidyltransferase " '.
27.
The systematic name of this enzyme class is "'NTP : alpha-D-aldose-1-phosphate nucleotidyltransferase " '.
28.
While it does provide access to every possible stereoisomer of any desired aldose, the process is limited in by its low yield and use of toxic reagents.
29.
At equilibrium the aldose and ketose form a mixture which in the case of the glyceraldehyde and dihydroxyacetone is also called "'glycerose " '.
30.
A reducing end of a carbohydrate is a carbon atom that can be in equilibrium with the open-chain aldehyde ( aldose ) or keto form ( ketose ).
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