Changes in rates and types of infection alone however, have been unable to explain the observed increase in allergic disease, and recent evidence has focused attention on the importance of the gastrointestinal microbial environment.
22.
The multicenter PARSIFAL study in 2006, involving 6630 children age 5 to 13 in 5 European countries, suggested that reduced use of antibiotics and antipyretics is associated with a reduced risk of allergic disease in children.
23.
The commercial use of beryllium requires the use of appropriate dust control equipment and industrial controls at all times because of the toxicity of inhaled beryllium-containing dusts that can cause a chronic life-threatening allergic disease in some people called berylliosis.
24.
The mechanism of action of the hygiene hypothesis was insufficient stimulation of the T H 1 arm, stimulating the cell defence of the immune system and leading to an overactive mother T H 2 arm, stimulating the antibody-mediated immunity of the immune systems, which in turn led to allergic disease.
25.
Site Specific UBITh Amyloid-? Vaccine Amyloid beta for Alzheimer disease, AIDS, and severe Allergic Disease Allergy; and for multiple animal health applications including pet contraception, Allergy, boar taint removal Boar taint and vaccine against infections caused by Porcine circovirus, Porcine Reproductive and Respiratory Syndrome Virus and Foot and mouth disease.
26.
The Purinergic receptor, P2Y12, while not directly binding or responding to CysLTs, appears to be activated as a consequence of activating CysLT1 : blockage of P2Y12 activation either by receptor depletion or pharmacological methods inhibits many of the CysLTR1-dependent actions of CysLTs in various cell types in vitro as well as in an animal model of allergic disease.
27.
|13 is http : / / www . ncbi . nlm . nih . gov / pubmed / 9645595 " Indoor environment of residential homes in Hong Kong-- relevance to asthma and allergic disease " 14 is http : / / www . ncbi . nlm . nih . gov / pubmed / 8831283 " Measurements of indoor and outdoor nitrogen dioxide concentrations using a diffusive sampler"
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