21. Combined oral contraceptive pills reduce the clearance of alprazolam, which may lead to increased plasma levels of alprazolam and accumulation. 22. Alprazolam , like other benzodiazepines, binds to specific sites on the GABA A gamma-amino-butyric acid receptor.23. The report found that alprazolam is the most common benzodiazepine for recreational use followed by clonazepam, lorazepam, and diazepam. 24. On a commercial scale, phosphorus tribromide is used in the manufacture of pharmaceuticals such as alprazolam , methohexital and fenoprofen. 25. Those who received alprazolam also had increased respiration rates ( 22.7 vs 18.3 breaths / min ). 26. And examiners will break down overdose reports of benzodiazepines ( sedatives ) into alprazolam ( Xanax ) and diazepam ( Valium ). 27. With alprazolam a short-acting benzodiazepine taken for 8 weeks, 65 % of patients experienced significant rebound anxiety. 28. The plasma concentrations of 4-hydroxyalprazolam and ?-hydroxyalprazolam relative to unchanged alprazolam concentration were always less than 4 %. 29. The tranquilizer alprazolam , marketed as Xanax, reduced PMS symptoms by at least half in 37 percent of women who took it. 30. Second-line medications are the anti-epileptics topiramate, gabapentin ( as monotherapy ) and levetiracetam, or benzodiazepines like alprazolam .