21. This treatise also described one of the earliest known cases of amenorrhea associated with a pituitary tumor. 22. "Amenorrhea " is the absence of a menstrual period in a woman of reproductive age. 23. If the mother was experiencing lactational amenorrhea her periods will return along with the return of her fertility. 24. Even short-term amenorrhea is associated with bone loss and negative long range effects on the cardiovascular system. 25. Women with PCOS show menstrual irregularities that range from oligomenorrhea and amenorrhea , to very heavy, irregular periods. 26. The researchers gave injections of Amgen's synthetic leptin to eight competitive women athletes, all with hypothalamic amenorrhea . 27. Persistent break through bleeding and amenorrhea commonly reflect an atrophic endometrium, which means a thin and not developed endometrium. 28. Although menstrual disorders are most strongly associated with Anorexia nervosa, Bulimia nervosa may also result in oligomenorrhea or amenorrhea . 29. It is one of the three major components of female athlete triad syndrome, along with amenorrhea and disordered eating. 30. Turner syndrome is a cause of primary amenorrhea , premature ovarian failure ( hypergonadotropic hypogonadism ), streak gonads and infertility.