The catalyst can also be used in a reductive amination reaction between a carboxylic acid and an amine with phenylsilane as the reducing agent.
22.
Ciganek describes an example of an intramolecular Chichibabin reaction in which a nitrile group on a fused ring is the source of nitrogen in amination.
23.
Another early application is the synthesis of unnatural chiral amino acids in a formal reductive amination for example starting from benzophenone and the hydrazone of benzoyl chloride:
24.
An example of the catalytic amination of aryl chloride with N-methylaniline at room temperature is shown in "'Scheme 3 " '.
25.
Aminotransferase enzymes can be used to synthesize chiral amines in non-racemic form either through kinetic resolution of a racemate or reductive amination of a prochiral ketone.
26.
Hydrastinine has also been found as an impurity or side product in MDMA synthesis performed by low pressure amination of 3, 4-methylenedioxyphenylpropan-2-one with methylamine.
27.
Merck s process chemistry department contracted Codexis, a medium-sized biocatalysis firm, to develop a large-scale biocatalytic reductive amination for the final step of its sitagliptin synthesis.
28.
The compound can be prepared by many methods, alkylation of picolinylamine with picolinyl chloride, deamination of picolinylamine, and reductive amination of picolinyl amine and pyridine-2-carboxaldehyde.
29.
In general, the repertoire of reactions utilized in discovery chemistry is somewhat narrow ( for example, the Buchwald-Hartwig amination, Suzuki coupling and reductive amination are commonplace reactions ).
30.
In general, the repertoire of reactions utilized in discovery chemistry is somewhat narrow ( for example, the Buchwald-Hartwig amination, Suzuki coupling and reductive amination are commonplace reactions ).
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