Consistent with the known enterohepatic cycling of the related antifolate methotrexate, oral activated charcoal, and saline cathartic or sorbitol may promote excretion if an overdose of aminopterin is suspected.
22.
That same year, Milunsky, Graef, and Gaynor reported cases of cleft lip and palate associated with attempted abortion with methotrexate and aminopterin, which are folic acid antagonists.
23.
In some cases the abortion didn�t happen, but the newborns suffered a fetal aminopterin syndrome consisting of growth retardation, craniosynostosis, hydrocephalus, facial dismorphities, mental retardation and / or leg defomities
24.
During the period Aminopterin was marketed, the agent was used off-label to safely treat over 4, 000 patients with psoriasis in the United States, producing dramatic clearing of lesions.
25.
Thus, when the ratio of folic acid to aminopterin was 200 : 1 and greater, all of the subjects survived on regimens that would have otherwise been uniformly fatal to all subjects.
26.
They include the cancer drugs aminopterin and methotrexate; sulfasalazine, an anti-inflammatory drug; pyrimethamine, used to treat protozoal infections; triamterene, a diuretic; and trimethoprim, an ingredient of the antibiotic Bactrim.
27.
Now in a more pure preparation and supported by laboratory evidence of superior tumor cell uptake " in vitro ", aminopterin is being investigated in clinical trials in leukemia as a potentially superior antifolate to methotrexate.
28.
Exposing cells to aminopterin ( a folic acid analogue, which inhibits dihydrofolate reductase, DHFR ), makes them unable to use the de novo pathway and become fully auxotrophic for nucleic acids, thus requiring supplementation to survive.
29.
Supralethal doses of aminopterin may be rescued with the antidote Leucovorin ( also known as "'folinic acid "'), a reduced form of folic acid which bypasses dihydrofolate reductase, the enzyme inhibited by aminopterin.
30.
Supralethal doses of aminopterin may be rescued with the antidote Leucovorin ( also known as "'folinic acid "'), a reduced form of folic acid which bypasses dihydrofolate reductase, the enzyme inhibited by aminopterin.
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