21. He has been involved in registration trials of antineoplastic agents in a variety of solid tumors. 22. The following nitrogen mustard ester of estradiol is an alkylating antineoplastic agent and has been marketed: 23. "' Carboxycyclophosphamide "'is an inactive metabolite of the cytotoxic antineoplastic drug cyclophosphamide. 24. The antineoplastic alkylating agent, teroxirone, is formed by reacting cyanuric acid with 3 equivalents of epichlorohydrin. 25. "' Lurtotecan "'is a semi-synthetic analog of camptothecin with antineoplastic activity. 26. Chromonychia can be induced by antineoplastic drugs with few distinct forms, the most frequently seen is melanonychia. 27. "' Exatecan "'is a drug which is an analogue of camptothecin with antineoplastic activity. 28. In the area of platinum-based antineoplastic agents, spectator ( and nonspectator ) ligands greatly affect efficacy. 29. "' Estramustine "'( synthetic steroidal estrogen and alkylating antineoplastic agent that was never marketed. 30. Indeed, staurosporine and its derivatives possess antineoplastic activity in vivo in human tumors grown as xenografts in nude mice.
