On 3 June 2009, the FDA published an alert " notifying healthcare professionals of the risk of serious liver injury, including liver failure and death, with the use of propylthiouracil . " As a result, propylthiouracil is no longer recommended in non-pregnant adults and in children as the front line antithyroid medication.
22.
There are studies of cell cultures, laboratory animals, wildlife, and accidentally exposed humans that show that environmental chemicals cause a wide range of reproductive, developmental, growth, and behavior effects, and so while " endocrine disruption in humans by pollutant chemicals remains largely undemonstrated, the underlying science is sound and the potential for such effects is real . " While compounds that produce estrogenic, androgenic, antiandrogenic, and antithyroid actions have been studied, less is known about interactions with other hormones.
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