The mechanism of action of itraconazole is the same as the other azole antifungals : it inhibits the fungal-mediated synthesis of ergosterol.
22.
The copper azole preservative incorporates organic triazoles such as tebuconazole or propiconazole as the co-biocide, which are also used to protect food crops.
23.
Consequently, the focus of azole research is beginning to shift towards identifying new ways to circumvent this major obstacle ( Becher et al . ).
24.
A series of enzymes then chemically alter the peptide to install its post-translational modifications, including several azole heterocycles and an N-terminal amine dimethylation.
25.
Although strictly speaking a homocyclic, inorganic compound, pentazole has historically been classed as the last in a series of heterocyclic azole compounds containing one to five nitrogen atoms.
26.
Control of the pathogen ( antifungal medication ) now relies on the application of azole fungicides which are demethylase inhibitors that inhibit lanosterol 14 alpha-demethylase ( CYP51 ) activity.
27.
Itraconazole is pharmacologically distinct from other azole antifungal agents in that it is the only inhibitor in this class that has been shown to inhibit both the hedgehog signaling pathway and angiogenesis.
28.
Oxidation of azoline heterocycles to azoles can also be accomplished by an oxidase ribosomal peptides, cyanobactins can include D-amino acids; these can occur adjacent to azole or azoline residues.
29.
Unlike most adverse effects, which are similar to other azole antifungal agents, visual disturbances ( such as blurred vision, color vision change or increased sensitivity to light ) are unique to voriconazole.
30.
Macrolide antibiotics including erythromycin and clarithromycin, as well as several of the newer classes of antifungals, especially of the azole class ( fluconazole, voriconazole ), increase tacrolimus levels by competing for cytochrome enzymes.
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