21. This conversion of cholesterol into bile acids lowers plasma cholesterol levels. 22. The more fat that people eat, the more bile acids that they secrete. 23. This enzyme is involved in a metabolic pathway that degrades bile acids into cholesterol. 24. Also 27 studies reported that bile acids cause programmed cell death ( apoptosis ). 25. Chenodeoxycholic acid is made by many species, and is the prototypic functional bile acid . 26. It acts as a hydrocholeretic, increasing bile output to clear increased bile acid load. 27. Bile acid sequestrants may also be used to treat hyperthyroidism as an adjunct therapy.28. EPHX1 mediates the sodium-dependent transport of bile acids into hepatocytes. 29. These same bile acids are substrates for the UGT2B4 enzyme. 30. There are additional secondary bile acids , such as ursodeoxycholic acid.
