21. But, the binding agents often continue to harden, leading to a loss of flexural strength over time. 22. This paste is mixed with chalk, coloured pigment and a binding agent to form a thick dye. 23. Also, plant pastes tend to smudge more easily than silk pastes due to the loose binding agent . 24. Hormel Foods Corp . will supply GM with a binding agent made from the animal protein collagen. 25. In the 19th century, Portland cement, a fine artificial powder, was the main binding agent in concrete. 26. As DNA minor groove binding agents , pyrrolobenzodiazepines bind and cross-link specific sites of DNA of the cancer cell. 27. Phenylahistin is a microtubule binding agent that exhibits cytotoxic activities against a wide variety of tumor cell lines. 28. The calcium carbonate of the freshwater mussels also acts as a binding agent and created a stronger vessel. 29. The flour batter acts as a binding agent for the granules ( peanuts, anchovy, shrimp, etc . ). 30. Other binding agents such as resins may be tough and possibly elastic but can neither bear filling material.