21. Rather, cytokines such as calmodulin kinase by increase in Ca 2 + concentrations. 22. The interdomain linker between the oxygenase and reductase domains contains a calmodulin -binding sequence. 23. This enables CamKII to be active, even in the absence of calcium and calmodulin . 24. NAD kinases in plants and sea urchin eggs have also been found to bind calmodulin . 25. However, calmodulin must remain bound to the enzyme for its activity to be sustained. 26. One of the first examples was the structure of calmodulin -binding domains bound to calmodulin. 27. One of the first examples was the structure of calmodulin-binding domains bound to calmodulin . 28. Four discrete regions of CyaA bind calcium-loaded calmodulin with a large buried contact surface. 29. The thin filament of smooth muscle is made of actin, tropomyosin, caldesmon, and calmodulin . 30. The ? subunit is the ubiquitous eukaryotic protein calmodulin which itself has 4 calcium ion binding sites.