21. Lutwak-Mann was known for discovering that the hormone progesterone acts on the placenta to control carbonic anhydrase synthesis. 22. Raul Rodriguez, Sponsel's attorney, said Sponsel undertook research into carbonic anhydrase inhibitors, some of it funded by Merck. 23. Carbonic anhydrase inhibitors decrease bicarbonate formation from ciliary processes in the eye, thus decreasing the formation of Aqueous humor.24. In the 1970s, he proposed the use of carbonic anhydrase ( CA ) inhibitor acetazolamide to heal peptic ulcers. 25. Topiramate selectively inhibits cytosolic ( type II ) and membrane associated ( type IV ) forms of carbonic anhydrase . 26. It exists as a number of isoenzymes, the most active of which is carbonic anhydrase II ( CA-II ). 27. Although cadmium has no known biological role in higher organisms, a cadmium-dependent carbonic anhydrase has been found in marine diatoms. 28. One study found that the majority of capillaries in cherry hemangiomas are fenestrated because of staining for carbonic anhydrase activity. 29. However, the gene product lacks carbonic anhydrase activity ( i . e ., the reversible hydration of carbon dioxide ). 30. Inward movement of bicarbonate via the Band 3 exchanger allows carbonic anhydrase to convert it to CO 2 for expiration.
