Researchers have had limited success in coaxing human stem cells to become pancreatic cells, cardiac cells and blood cells .-----How close are the answers?
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The cardiac cells which propagate the action potential are quite distinct in form and function from the cells that make up the enteric nervous system.
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Technion scientists, for instance, already reported they have guided stem cells to transform into precursor cardiac cells that in the laboratory dish beat like a heart.
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"These results in isolated cardiac cells need to be validated in the whole human heart, but we're optimistic that this goal will be accomplished, " he said.
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The refractory period in cardiac physiology is related to the ion currents that, in cardiac cells as in nerve cells, flow into and out of the cell freely.
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However, it has been suggested that this drug has a compromised efficacy as a cardiac differentiation factor because it promotes the transdifferentiation of cardiac cells to skeletal myocytes.
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Lieber has also developed nanoelectronic devices for cell / tissue electrophysiology, showing that electrical activity and action potential propagation can be recorded from cultured cardiac cells with high resolution.
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However, phase 4 is also special and very important because all cardiac cells that belong to the excitatory system have an unstable phase 4 slope, a condition known as automaticity.
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Free long-chain fatty acids or those that are joined with carnitine can affect the electrical properties of cardiac cells causing an irregular heart beat ( arrhythmia, which can lead to cardiac arrest ).
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Decreased expression of CARP in cardiac cells within the ischemic region was detected in a rat model of ischemic injury, and was thought to be linked to the induction of GADD153, an apoptosis-related gene.
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