Contrary to this, a recent study has discovered Pak1 plays a cardioprotective role during the pathogenesis of cardiac hypertrophy and thus heart failure.
22.
In addition to the adenovirus listed prominently on the death certificate, the other conditions included cardiac hypertrophy, or the enlargement of the heart.
23.
HDAC9 KO mice are shown to suffer from cardiac hypertrophy which is exacerbated in mice that are double KO for HDACs 9 and 5.
24.
The interaction between DSCAM and COL6A2 and their combined effects were also observed in the H9c2 cardiac cell line with incidence of cardiac hypertrophy.
25.
LCAD knockout mice displayed a higher level of cardiac hypertrophy, as indicated by increased left ventricular wall thickness and an increased about of metabolic cardiomyopathy.
26.
The insight comes from the scientists'discovery of what they believe is a key step in a condition called cardiac hypertrophy, or enlargement of the heart.
27.
His doctorate at the University of Minnesota in 1969 was on the Morphology of Myosin and Thick Filament Diameter in Experimental Cardiac Hypertrophy .
28.
Moreover, Lumizyme is FDA approved as replacement therapy for late-onset ( noninfantile ) Pompe disease without evidence of cardiac hypertrophy in patients 8 years and older.
29.
Regarding the mechanistic role of beta-catenin in cardiac hypertrophy, transgenic mouse studies have shown somewhat conflicting results regarding whether upregulation of beta-catenin is beneficial or detrimental.
30.
In addition, in mice subjected to pressure overload-induced cardiac hypertrophy, inducing hypertrophic cardiomyopathy, paxillin expression levels increased, suggesting a role for paxillin in both types of cardiomyopathy.
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