21. Fearing Sherrord would confess to the police, Spinelli gave him whiskey that she had laced with chloral hydrate . 22. Chloral hydrate , first synthesized in 1832, was the first depressant developed for the specific purpose of inducing sleep.23. Reaction with chloral hydrate in the presence of potassium bisulfate yields the lactone of tetra-oxydiphenyl methane carboxylic acid. 24. The hypnotic Lambert found best contained chloral hydrate and morphine along with one or two grams of paraldehyde. 25. How much chloral hydrate would need to be diluted in ethanol to work as a " Mickey Finn "? 26. Typically chloral hydrate is given orally or rectally by a nurse or nurse practitioner who would monitor the child. 27. Marshall admitted that he had also prescribed chloral hydrate to his recently deceased wife, Faye, as a headache medicine. 28. She had trouble sleeping and was being given natural supplements and the drug chloral hydrate to help her sleep. 29. It seems likely that she knelt over the bathtub, took chloral hydrate , and plunged her head in the water. 30. According to biographer Jean-Paul Goujon, Vivien suffered from chronic gastritis, due to years of chloral hydrate and alcohol abuse.