21. The situation is worse if drugs such as chloroquine are used which accumulate progressively. 22. Traditional treatments such as the drug chloroquine are losing effectiveness as the parasite develops resistance. 23. Barman said mosquitoes appear to have become resistant to the commonly used drug, chloroquine . 24. Adverse reactions are generally similar in severity and type to that seen in chloroquine treatment. 25. The first type of resistance to be acknowledged was to chloroquine in Thailand in 1957. 26. It is related to chloroquine and mefloquine. 27. This MDA comprised 300 mg chloroquine base and 45 mg pyrimethamine weekly for nine weeks. 28. It was then decided to mix the remaining stock of pyrimethaminized salt with chloroquine powder. 29. A fresh batch of chloroquine tablets was sent to treat 200 patients still suffering from malaria. 30. Chloroquine , the cheapest and safest malaria drug is rapidly losing its effectiveness, he said.
