In general, acute toxicity occurs at doses of 25, 000 kg of body weight, with chronic toxicity occurring at 4, 000 IU / kg of body weight daily for 6 15 months.
22.
Acute toxicity is distinguished from chronic toxicity, which describes the adverse health effects from repeated exposures, often at lower levels, to a substance over a longer time period ( months or years ).
23.
The Safer Choice Standard and the Criteria for Safer Chemical Ingredients are protective and address a broad range of potential toxicological effects ( e . g ., carcinogenicity, chronic toxicity and aquatic toxicity ).
24.
Bromide compounds, especially sodium bromide, remained in over-the-counter sedatives and headache remedies ( such as the original formulation of Bromo-Seltzer ) in the US until 1975, when bromides were outlawed in all over-the-counter medicines, due to chronic toxicity.
25.
"There always was a warning, but I don't think it really hit the message that fluoride is a drug and has been associated with both acute and chronic toxicity, " said Linda Katz, deputy director for over-the-counter drug products at the FDA.
26.
The authors recommended further study of species-and development-stage chronic toxicity, of environmental glyphosate levels, and ongoing analysis of data relevant to determining what if any role glyphosate might be playing in worldwide amphibian decline, and suggest including amphibians in standardized test batteries.
27.
Both the acute and the chronic toxicity of an extract as specified under Description is very low; accordingly, the LD50 in the mouse was 7725 mg / kg body weight after oral application and 1100 mg / kg body weight after intravenous application.
28.
The ASA noted that Rawlins'quote referred to the use of animal testing in " long-term carcinogenicity studies with known genotoxic compounds or compounds that produced hyperplasia in chronic toxicity tests only, " and did not imply that he was against all animal testing.
29.
In addition to the tests required to move a novel drug into the clinic for the first time, manufacturers must ensure that any long-term or chronic toxicities are well-defined, including effects on systems not previously monitored ( fertility, reproduction, immune system, among others ).
30.
In a similar way to aluminium salts, indium ( III ) ions can be toxic to the kidney when given by injection, but oral indium compounds do not have the chronic toxicity of salts of heavy metals, probably due to poor absorption in basic conditions.
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