I'm kind of puzzled by the 7-membered cyclisation step in the article's given synthesis of clozapine, I would expect the amide center to be very non-electrophilic ( being an amide, having a phenyl ring donating into it + enamine donating electrons by proxy ) . talk ) 18 : 17, 21 April 2010 ( UTC)
22.
From here it was but a short step to the geometric, and more obviously chemically relevant, view that in the internal cyclisation of a diene, the top face of one terminal atom should attack the bottom face of the other, while in the triene case, the formation of a new bond should involve the top ( or pari passu, the bottom ) faces of both terminal atoms . ""
23.
C 15 ) as the cyclisation of farnesyl pyrophosphate cannot produce two dimethylate carbons that are separated by a single carbon nor would this be consistent with the natural occurrence of similar compounds with different keto-aryl side-chains in the members of the " Myrtaceae " ( " eg . " flavesone, papuanone, isoleptospermone and grandiflorone and could be the intermediate, but other routes of biosynthesis may be possible, such as via isobutyryl-CoA, the result of the decarboxylative condensation of ketoisovalerate ( ketone form of valine ) ( cf . polyketides ).
24.
By the middle of the 12th century, the corpus of works was being expanded principally by " cyclisation ", that is to say by the formation of " cycles " of " chansons " attached to a character or group of characters with new " chansons " being added to the ensemble by singing of the earlier or later adventures of the hero, of their youthful exploits ( " enfances " ), the great deeds of their ancestors or descendants, or their retreat from the world to a convent ( " moniage " ) or attached to an event ( like the Crusades ).
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