21. De novo gene changes occur randomly and are not the fault of either parent.22. Lutefisk can solve de novo sequencing from CID mass spectra. 23. IMP dehydrogenase 2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. 24. Using this information, de novo predictors can discriminate amongst decoys. 25. Hernandez et al . found that LTP increases de novo synthesis of PKM ?. 26. De novo " organogenesis can then occur from those cells.27. De novo biosynthesis of purine nucleotides is fairly complex, consisting of several enzymatic reactions.28. During early de novo " production of endothelial cells which then form vascular tubes. 29. The main song : " Quero Sentir de Novo ". 30. A second category is de novo design of new ligands.