21. This gene encodes a DNA-editing deaminase that is a member of the cytidine deaminase family. 22. The enzymes threonine deaminase , dihydroxy acid dehydrase and transaminase are controlled by end-product regulation. 23. Michael Neuberger discovered the mechanism by which antibody diversification occurs by Activation-induced ( cytidine ) deaminase . 24. PBG is then converted into hydroxymethyl bilane by the enzyme porphobilinogen deaminase , also known as hydroxymethylbilane synthase. 25. This disease is caused by mutation in the double stranded RNA specific adenosine deaminase ( ADAR1 ) gene. 26. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. 27. More specifically, the catalytic domain is a zinc dependent cytidine deaminase domain and is essential for cytidine deamination. 28. In some bacterial species it is also involved in the degradation of arginine ( the arginine deaminase pathway ). 29. Figure 1 : Structure model of the N-terminal [ catalytic deaminase domain ] of [ APOBEC3G ]. 30. It is a " transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates.
