21. Sulpiride, along with clozapine, has been found to activate DNA demethylation in the brain. 22. Current antipsychotic drugs, like clozapine and sulpiride, have been shown to also induce demethylation . 23. Maeder et al . has constructed a ZF-TET1 protein for use in DNA demethylation . 24. After N-demethylation of oxymorphone, noroxymorphone is further glucuronidated to noroxymorphone-3-glucuronide. 25. Histones H3 and H4 can also be manipulated through demethylation using histone lysine demethylase ( KDM ). 26. The demethylation occurs when JmjC utilizes multiple cofactors to hydroxylate the methyl group, thereby removing it. 27. Further processing of aristolactam I by O-demethylation results in aristolactam Ia, the primary metabolite. 28. Codeine is metabolised by O-and N-demethylation in the liver to morphine and norcodeine. 29. The demethylation of sarcosine catalyzed by sarcosine dehydrogenase can proceed with or without the presence of tetrahydrofolate. 30. They prevent the demethylation of the H3K4 histone protein and open up that part of the chromatin.
