After completing several successful contracts with large diagnostic manufacturers, the company launched a related service, PCRstable, that focused specifically on improving stability of PCR-based, molecular diagnostic assays, including those using microfluidic chips and specialized cartridges and cassettes.
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"' Flow-through tests "'or "'immunoconcentration assays "'are a type of diagnostic assay that allows users to test for the presence of a biomarker, usually a specific antibody, in a sample such as blood.
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"' Janssen Biotech, Inc . "', formerly "'Centocor Biotech, Inc . "', is a biotechnology company that was founded in Philadelphia in 1979 with an initial goal of developing new diagnostic assays using monoclonal antibody technology.
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One such kit is the " Trupoint " diagnostic assay from PerkinElmer, Inc . This assay is a time-resolved fluorescence quenching assay that utilizes the PerkinEmer " SignalClimb " technology that is based on two labels that bind in close proximity to one another but on opposite DNA strands.
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A monoclonal antibody against the IgV domain of TIM-1, ARD5, blocked EBOV binding and infection . Together, these studies suggest NPC1 and TIM-1 may be potential therapeutic targets for an Ebola anti-viral drug and as a basis for a rapid field diagnostic assay.
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Section [ 0037 ] of the patent explains its purpose as having utility in design of diagnostic assays to monitor Ebola HF [ Hemorrhagic Fever ] disease in humans and animals, and develop effective antivirals and vaccines . Further, to avoid limiting the extent and reach of the patent, Section [ 0036 ] states that:
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In the early 1990s, the in-vitro diagnostic assay business was divested to a joint venture with Eastman Kodak called Amerlite Diagnostics Ltd, this was later wholly acquired by Eastman Kodak and renamed Kodak Clinical Diagnostics Ltd . This business was sold by Kodak to Johnson & Johnson and became known as Johnson & Johnson Clinical Diagnostics Ltd . The business is now called Ortho-Clinical Diagnostics Ltd, but is still owned by Johnson & Johnson.
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