The catalytic activity of gamma-butyrobetaine dioxygenase can be stimulated with different metal ions, especially potassium ions.
22.
Tryptophan 2, 3-dioxygenase was initially discovered in the 1930s and is found in both eukaryotes and prokaryotes.
23.
It has been shown that tryptophan 2, 3-dioxygenase is expressed in a significant proportion of human tumors.
24.
In the same study, tryptophan 2, 3-dioxygenase expression by tumors prevented their rejection by immunized mice.
25.
Inhibition of indoleamine 2, 3-dioxygenase, a target of the cancer suppression gene Bin1, potentiates cancer chemotherapy.
26.
Several " in vitro " biochemical assays have been applied to monitor the catalytic activity of gamma-butyrobetaine dioxygenase.
27.
The enzyme belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are involved in methionine salvage.
28.
Normally, the breakdown of the amino acid tyrosine involves the conversion of 4-hydroxyphenylpyruvate to homogentisate by 4-Hydroxyphenylpyruvate dioxygenase.
29.
Top : FAD-dependent amine oxidase mechanism of lysine demethylation Bottom : Fe ( II ) and ?-ketoglutarate-dependent dioxygenase
30.
Another study showed that tryptophan 2, 3-dioxygenase is potentially involved in the metabolic pathway responsible for anxiety-related behavior.
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