21. Genome replication is initiated when a viral endonuclease ( gp2 ) nicks the double stranded intermediate. 22. The intein contains a self-cleaving domain, which has the endonuclease nested within it. 23. Xeroderma pigmentosa is a rare, autosomal recessive disease caused by a defective UV-specific endonuclease . 24. Protein A is a single strand endonuclease and is responsible for the initiation of viral DNA replication. 25. XPF provides the endonuclease active site and is involved in DNA binding and additional protein protein interactions. 26. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'- side of pyrimidine bases. 27. This relationship suggested that AP endonuclease originated from a retrotransposon insertion either nearby or within a Helitron. 28. However, if genomic DNA is treated with a particular restriction endonuclease many DSBs will be created. 29. "' NlaIII "'is an endonuclease that cleaves double stranded DNA molecules into fragments: 30. The protein has endonuclease activity on 5'and 3'overhangs and hairpins when complexed with PRKDC.
