21. Vitamin K 2, 3-epoxide is activated by reduction via the VKORC enzyme. 22. But the epoxide product itself is vulnerable to ring opening, isn't it? 23. This sulfone is coupled with a straightforward epoxide that originates from optically active starting materials. 24. Glycidamide can also be hydrolyzed to glyceramide both spontaneously or enzymatically by microsomal epoxide hydrolase. 25. The epoxide also dissolves more easily in water than its parent compound and is more persistent. 26. The epoxide was present for 4 steps before being removed with samarium ( II ) oxide. 27. Nucleophilic opening of this epoxide can occur by attack at either the 1 or 2 position. 28. This epoxide intermediate allowing radical reactions to eventually open and oxidize the six-membered ring. 29. One of violaxanthin s two epoxide groups are removed from its chemical structure to generate antheraxanthin. 30. Other enzymes that may also produce mutagenic metabolites include glutathione S-transferase and microsomal epoxide hydrolase.
