21. It binds physically to ergosterol within the membrane, thus creating a polar pore in fungal membranes. 22. Its structure was determined in 1954 by comparison with a sample that was chemically synthesized from ergosterol . 23. Preparations of irradiated ergosterol containing a mixture of previtamin and D vitamin were called Viosterol in the 1930s. 24. Like other imidazole antifungals, sertaconazole blocks the synthesis of ergosterol by inhibiting the 14?-demethylase enzyme. 25. Both Itraconazole and Fluconazole inhibits the synthesis of ergosterol which is an important component of fungal cell membranes. 26. Squalene epoxidase contributes to the formation of ergosterol Terbinafine, inhibits squalene epoxidase thereby preventing cell membrane formation. 27. Also known to be present are various steroids, namely ergosterol , episterol, fecosterol, and lichesterol. 28. Some studies test for changes in the production of important downstream ergosterol intermediates in the presence of these compounds. 29. Ergocalciferol ( D2 ) is derived from ergosterol from UV-exposed mushrooms or yeast and is suitable for vegans. 30. The cell membranes of fungi contain ergosterol in place of cholesterol, allowing them to produce compounds that inhibit cholesterol.
