21. Also dihydrotestosterone and the ratio of free testosterone to estradiol increased significantly. 22. It is an estrogen ester, specifically, an ester of estradiol . 23. ESTRADIOL : Hormone secreted by cells that line the inside of a follicle.24. The plant-derived estrogens are known as estradiol , estrone and estriol. 25. Estradiol is an estrogen that is considered an important promoter of breast cancer.26. The body converts estradiol and estrone into one another. 27. Estradiol is also metabolized via hydroxylation into catechol estrogens.28. During pregnancy, estrogen levels, including estradiol , rise steadily toward term. 29. A similarly small fraction of serum estradiol is bound to transcortin as well. 30. The side effects of estradiol valerate are the same as those of estradiol.